Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
نویسندگان
چکیده
منابع مشابه
Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel
The intense pain induced by scorpion sting is a frequent clinical manifestation. To date, there is no established protocol with significant efficacy to alleviate the pain induced by scorpion envenomation. One of the important reasons is that, little information on pain-inducing compound from scorpion venoms is available. Here, a pain-inducing peptide (BmP01) has been identified and characterize...
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The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through these channels.
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Venomous animals use peptide toxins for hunting and self-defense. To achieve these goals, toxins need to bind to their targets with high affinity due to the small amount that a single bite or sting can deliver. The scorpion toxin BmP01 is linked to sting-induced excruciating pain; however, the reported minimum concentrations for activating TRPV1 channel or inhibiting voltage-gated potassium (Kv...
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This review categorizes functionally validated actions of defined scorpion toxin (SCTX) neuropeptides across ion channel subclasses, highlighting key trends in this rapidly evolving field. Scorpion envenomation is a common event in many tropical and subtropical countries, with neuropharmacological actions, particularly autonomic nervous system modulation, causing significant mortality. The prim...
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Chronic neuropathic pain is notoriously difficult to treat. Standard pain drugs, even narcotic opioid analgesic agents, often provide unsatisfactory pain relief. The need for better drugs is universally recognized. However, despite a substantial investment of resources by the pharmaceutical industry to identify alternative treatments, the effective management of chronic pain remains an unmet me...
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ژورنال
عنوان ژورنال: Toxins
سال: 2015
ISSN: 2072-6651
DOI: 10.3390/toxins7093671